Melatonin MT2 receptors in the descending antinociceptive pathway and reward: the role of
the opioid system Page 1 Melatonin MT2 receptors in the descending antinociceptive …

… MT 1 /MT 2 agonist, the N-phenyl derivative (UCM765) showed … for the MT 2 receptor and a
partial agonist behavior, and … sole MT 2 receptor may be sufficient to elicit an anxiolytic effect […

… concrete mechanisms that melatonin protects against … melatonin receptor agonists have a
long half-life, high absorption rate, and more obvious curative effects compared with melatonin …

… as a melatonin (MT 1 /MT 2 ) receptor agonist and 5-HT 2C … ) has been reported to mimic the
anxiolytic properties of MT, … -mentioned MT 2 receptor agonist UCM765 activates neurons in …

… The affinity of UCM871 at human MT 1 and MT 2 receptors … of MT 1 upon activation induced
by UCM871, we compared … the selective MT 1 receptors partial agonist UCM871 reverted …

… Here, we show age-dependent differences in the effects of MLT in anxiety paradigms and in
… 1) the selective MT 2 receptor’s partial agonist UCM765 induces anxiolytic-like effects in rats …

… effects, and a partial agonism at the serotonin 1A receptor, … Melatonin’s anxiolytic effects
might be associated with direct … The selective stimulation of MT2 receptors by UCM765 …

… melatonin (MT)-2 receptors 64., 65., 66.. Our results confirm the anxiolytic effects of melatonin,
… group showed an increased time at the center of the arena compared to the other groups. …

… UCM765 (39) is a selective MT 2 partial agonist which has been reported to promote non-rapid
eye movement sleep maintenance (40) and has anxiolytic (… We hypothesize that UCM765 …

… Anxiolytic effects of the melatonin MT(2) receptor partial agonist UCM765: comparison with
melatonin and diazepam… Prog Neuropsychopharmacol Biol Psychiatry, 39(2), 318325. doi:…